Feb. 17, 2025, 4:24 p.m.

MoKa 5 released

We are very happy to announce the immediate availability of MoKa 5, our physicochemical properties prediction software (pKa, logP/D, Solubility).

Notable changes in the new MoKa 5 include:

• Proteolysis Targeting Chimeras (PROTAC) mode, with specific prediction algorithms for their physicochemical properties
• improved lipophilicity (logP/logD) models with curated experimental data
• salting in/out effect for pH/solubility profiles
• vastly improved graphical interface with:
  • one-panel view for all the predictions and properties
  • flexible naming policy for input structures
  • multi-threading predictions engine
  • self-encapsulated work session data, allows easy resuming previous work and sharing structures with associated predictions
• further refinement of pKa internal model with new experimental data

More information about MoKa 5 can be found on the product page, and in the manual